Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning
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چکیده
منابع مشابه
Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning
BACKGROUND Remote ischemic perconditioning (RIPerC) has a promising therapeutic insight to improve the prognosis of acute myocardial infarction. Chronic comorbidities such as diabetes are known to interfere with conditioning interventions by modulating cardioprotective signaling pathways, such as e.g., mTOR pathway and autophagy. However, the effect of acute hyperglycemia on RIPerC has not been...
متن کاملAcute hyperglycemia abolishes ischemic preconditioning in vivo.
Ischemic preconditioning provides a powerful means to reduce myocardial infarct size in vivo and has been proposed to limit the extent of myocardial infarction in patients. In contrast, hyperglycemia correlates with increases in mortality after acute myocardial infarction. Thus we hypothesized that acute hyperglycemia alters the protection afforded by ischemic preconditioning, and this hypothes...
متن کاملInvestigating the role of acute and repeated stress on remote ischemic preconditioning-induced cardioprotection
Objective(s): To study the effect of acute and repeated stress on cardioprotection-induced by remote ischemic preconditioning (RIPC).Materials and Methods: RIPC was induced by giving 4 short cycles of ischemia and reperfusion, each consisting of five min. The Langendorff’s apparatus was used to perfuse the isolated rat hearts by subjecti...
متن کاملAcute Hyperglycemia Abolishes Ischemic Preconditioning by Inhibiting Akt Phosphorylation: Normalizing Blood Glucose before Ischemia Restores Ischemic Preconditioning
UNLABELLED This study examined the hypothesis that acute hyperglycemia (HG) blocks ischemic preconditioning (IPC) by inhibiting Akt phosphorylation. Brief HG of approximately 400 mg/dL was induced in C57BL/6 mice via intraperitoneal injection of 20% dextrose (2 g/kg). All mice underwent 40 min LAD occlusion and 60 min reperfusion. The IPC protocol was 2 cycles of 5 min ischemia and 5 min reperf...
متن کاملCirculating nitrite contributes to cardioprotection by remote ischemic preconditioning.
RATIONALE Remote ischemic preconditioning (rIPC) with short episodes of ischemia/reperfusion (I/R) of an organ remote from the heart is a powerful approach to protect against myocardial I/R injury. The signal transduction pathways for the cross talk between the remote site and the heart remain unclear in detail. OBJECTIVE To elucidate the role of circulating nitrite in cardioprotection by rIP...
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ژورنال
عنوان ژورنال: Cardiovascular Diabetology
سال: 2015
ISSN: 1475-2840
DOI: 10.1186/s12933-015-0313-1